Semblance Hypothesis

  (towards a theory since 2017)

Galapagos of neuroscience


There are large number of symptoms and signs in “loss of function” states of the system manifested as neurological and psychiatric disorders. Several unrelated disorders have certain similar features. In addition, it is possible to examine the effect of large number of pharmaceutical agents in these conditions. Often it is found that one pharmaceutical agent produces improvement of symptoms in several disparate neurological and psychiatric disorders. These findings immediately open huge possibility for undertaking a scientific approach to verify any hypothesis of nervous system functions. In this context, semblance hypothesis is examined. It is not possible to understand the details of all the findings now. However, both the similarities and the diagonally opposite findings in various disorders and the observed effects of pharmaceutical agents can be used to examine whether we can make inter-connectable explanations that make sense. At this stage of inquiry, the inferences that can be arrived are expected to provide huge benefits towards understanding the details of the normal operation of the system. This is going to be a very long journey and it reminds me of the journey of Charles Darwin in the Galapagos Islands.

Readers are expected to have finished reading at least the first and the FAQ page of this website before examining the rest of this webpage to get an understanding of what we can infer from the observations from “loss of function” states of different disorders. Specific references to publications are provided wherever necessary. The contents of this webpage is a very primitive rough draft of a new project that I have undertaken. This page was started with the idea that dissemination of these findings should not be delayed since so many people are suffering from neurological and psychiatric disorders and I believe that such an effort will be in their expectations at this stage of a hypothesis of nervous system functions.

As the journey begins, our key question is, “If the semblance hypothesis is correct, what would we find in a particular disorder?” “Can the observations in a disorder and the effect a specific pharmaceutical agent make sense in the light of the hypothesis?” Please note that at this stage, we may not be able to find explanations for all the findings in every disorder. If the hypothesis is correct, then it is reasonable to find large number of observations that should make sense and we should have inter-connectable explanations for various findings in different disorders. I must admit that I was implicitly influenced by findings from large number of nervous system disorders during the development of the semblance hypothesis. However, a conscious effort to examine majority of these findings in terms of the hypothesis was carried out only after the initial derivation of the hypothesis.

Without further ado, let us begin our journey (Will continue….)